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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Them4tm1Hem
targeted mutation 1, Brian Hemmings
MGI:3848835
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Them4tm1Hem/Them4tm1Hem involves: 129P2/OlaHsd * C57BL/6 MGI:3848907


Genotype
MGI:3848907
hm1
Allelic
Composition		 Them4tm1Hem/Them4tm1Hem
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Them4tm1Hem mutation (0 available); any Them4 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Elongated mitochondria in Them4tm1Hem/Them4tm1Hem liver

liver/biliary system
abnormal hepatocyte mitochondrial morphology ( J:149552 )
• hepatocyte mitochondria are elongated instead of round and compact as in wild-type mice

cellular
cellular phenotype ( J:149552 )
N
• mitochondrial biogenesis is normal
abnormal hepatocyte mitochondrial morphology ( J:149552 )
• hepatocyte mitochondria are elongated instead of round and compact as in wild-type mice

reproductive system
reproductive system phenotype ( J:149552 )
N
• mice are fertile




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory