Phenotypes associated with this allele

• Allele Symbol: Sema3e^{tm1(cre/ERT2)Arbr}
• Allele Name: targeted mutation 1, Silvia Arber
• Allele ID: MGI:3848810
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sema3e^tm1(cre/ERT2)Arbr/Sema3e^tm1(cre/ERT2)Arbr	involves: 129P2/OlaHsd * C57BL/6	MGI:3848831
cn2	Sema3e^tm1(cre/ERT2)Arbr/Sema3e^tm1(cre/ERT2)Arbr	involves: 129P2/OlaHsd	MGI:5550519

Genotype
MGI:3848831

hm1

• Allelic Composition: Sema3e^{tm1(cre/ERT2)Arbr}/Sema3e^{tm1(cre/ERT2)Arbr}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:149553 )

N • mice exhibit normal positions of the cell bodies and dendrites of cutaneous maximus or triceps motor neurons

abnormal motor neuron morphology ( J:149553 )

• mice exhibit a 3-fold increase in the number of proprioceptive synaptic contacts with identified cutaneous maximus motor neurons compared to in wild-type mice

abnormal motor neuron innervation pattern ( J:149553 )

• 45% of cutaneous motor neurons receive monosynaptic input after stimulation of cutaneous maximus afferents unlike wild-type motor neurons

• however, monosynaptic specificity from the tricep is normal

behavior/neurological

behavior/neurological phenotype ( J:149553 )

N • mice exhibit no behavior deficits

Genotype
MGI:5550519

cn2

• Allelic Composition: Sema3e^{tm1(cre/ERT2)Arbr}/Sema3e^{tm1(cre/ERT2)Arbr}
• Genetic Background: involves: 129P2/OlaHsd

nervous system

nervous system phenotype ( J:205528 )

N • normal motor neuron positioning at caudal lumbar levels and Glu motor neuron dendrite arborization (at P10) comparing to heterozygous animals

N • the patterns of hamstring knee flexor muscle and gluteus homonymous monosynaptic sensory-motor connections are similar to controls

abnormal excitatory postsynaptic potential ( J:205528 )

• a large amplitude of monosynaptic EPSP is seen in 44% of gluteus motor neurons unlike in controls