Phenotypes associated with this allele

• Allele Symbol: Hsf4^tm1Xyk
• Allele Name: targeted mutation 1, Xiangyin Kong
• Allele ID: MGI:3848361
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hsf4^tm1Xyk/Hsf4^tm1Xyk	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3848441
cx2	Hsf4^tm1Xyk/Hsf4^tm1Xyk Crygs^rncat/Crygs^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * Kunming	MGI:3848445

Genotype
MGI:3848441

hm1

• Allelic Composition: Hsf4^tm1Xyk/Hsf4^tm1Xyk
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Lens abnormalities and developmental defects in Hsf4^tm1Xyk/Hsf4^tm1Xyk mice

vision/eye

abnormal lens morphology ( J:149354 )

• lighter in weight but normal in size

• lens is fragile

• reduced levels of all gamma-crystallins immediately after birth

abnormal lens fiber morphology ( J:149354 )

• structure of fibers becomes loose

• vacuole-like cavity appears in lense fiber cells at day E15.5 becoming severe with time

Genotype
MGI:3848445

cx2

• Allelic Composition: Hsf4^tm1Xyk/Hsf4^tm1Xyk; Crygs^rncat/Crygs⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * Kunming

vision/eye

cataract ( J:149354 )

• cataracts develop in the posterior part of the lens by about 7 days of age