Phenotypes associated with this allele

• Allele Symbol: Ampd2^m4521Dajl
• Allele Name: mutation 4521 David J Lloyd
• Allele ID: MGI:3848348
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ampd2^m4521Dajl/Ampd2^m4521Dajl	involves: C3H/HeSnJ * C57BL/6J * SWR	MGI:3848352

Genotype
MGI:3848352

hm1

• Allelic Composition: Ampd2^m4521Dajl/Ampd2^m4521Dajl
• Genetic Background: involves: C3H/HeSnJ * C57BL/6J * SWR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating cholesterol level ( J:149088 )

• at 9 weeks, 81% of male and 54% of female mice exhibit hypercholesterolemia compared to wild-type mice

• overall, 99% of male and 63% of female mice exhibit hypercholesterolemia compared to C3H wild-type mice

• however, cholesterol levels return to normal at later ages

increased circulating LDL cholesterol level ( J:149088 )

increased circulating triglyceride level ( J:149088 )

• in some mice

growth/size/body

decreased body weight ( J:149088 )

• slightly