Phenotypes associated with this allele

• Allele Symbol: Dppa4^tm1.1Hjf
• Allele Name: targeted mutation 1.1, H J Felhing
• Allele ID: MGI:3848331
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dppa4^tm1.1Hjf/Dppa4^tm1.1Hjf	B6.129P2-Dppa4^tm1.1Hjf	MGI:3848333

Genotype
MGI:3848333

hm1

• Allelic Composition: Dppa4^tm1.1Hjf/Dppa4^tm1.1Hjf
• Genetic Background: B6.129P2-Dppa4^tm1.1Hjf

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:149143 )

• some mice die between E18.5 and P1

postnatal lethality, incomplete penetrance ( J:149143 )

• 10-fold fewer mice than expected are present at weaning

• most mice die after birth

reproductive system

reduced female fertility ( J:149143 )

♀ • despite normal germ cells development, one of 3 females fail to produce offspring and a second female only gave birth to one liter within 12 months

♀ • female mice fail to produce offspring when mated to homozygous male mice despite normal male fertility when mated to wild-type mice

skeleton

asymmetric sternocostal joints ( J:149143 )

• in 7 of 26 mice

abnormal sternum ossification ( J:149143 )

• reduced in 24 of 26 mice

split xiphoid process ( J:149143 )

abnormal rib morphology ( J:149143 )

• in 24 of 26 mice rib ossification is reduced compared to in wild-type mice

respiratory system

abnormal lung morphology ( J:149143 )

• in embryos and newborns

abnormal pulmonary alveolus morphology ( J:149143 )

• at E18.5, mice exhibit reduced alveolar space compared to in wild-type mice

atelectasis ( J:149143 )

• at E18.5, lungs are poorly inflated unlike in wild-type mice

growth/size/body

decreased fetal size ( J:149143 )

• at E18.5

cellular

maternal effect ( J:149143 )

• female mice fail to produce offspring when mated to homozygous male mice despite normal male fertility when mated to wild-type mice