All Phenotypes Prokr1<tm1.1Cagn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Prokr1^tm1.1Cagn
targeted mutation 1.1, Canan G Nebigil
MGI:3848169

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prokr1^tm1.1Cagn/Prokr1^tm1.1Cagn	Not Specified	MGI:3848195

Allelic Composition	Prokr1^tm1.1Cagn/Prokr1^tm1.1Cagn
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prokr1^tm1.1Cagn mutation (0 available); any Prokr1 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:149020 )

N	• mice survive into adulthood

cardiovascular system

decreased capillary density ( J:149020 )

• capillary density in the subepicardium is decreased by 22% compared to in wild-type hearts

abnormal heart morphology ( J:149020 )

• capillary density in the subepicardium is decreased by 22% compared to in wild-type hearts

abnormal cardiovascular system physiology ( J:149020 )

• cardiac explants are no longer responsive to prokineticin-2 unlike wild-type explants

reproductive system

reproductive system phenotype ( J:149020 )

N	• mice are fertile

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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