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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Akt3tm1Nhy
targeted mutation 1, Nissim Hay
MGI:3848061
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Akt1tm1Nhy/Akt1+
Akt2tm1Rsg/Akt2tm1Rsg
Akt3tm1Nhy/Akt3tm1Nhy 		involves: 129/Sv * C57BL/6 * DBA/1LacJ MGI:3848164
cx2
 		Akt2tm1Rsg/Akt2tm1Rsg
Akt3tm1Nhy/Akt3tm1Nhy 		involves: 129/Sv * C57BL/6 * DBA/1LacJ MGI:3848166


Genotype
MGI:3848164
cx1
Allelic
Composition		 Akt1tm1Nhy/Akt1+
Akt2tm1Rsg/Akt2tm1Rsg
Akt3tm1Nhy/Akt3tm1Nhy
Genetic
Background		 involves: 129/Sv * C57BL/6 * DBA/1LacJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1tm1Nhy mutation (0 available); any Akt1 mutation (37 available)
Akt2tm1Rsg mutation (0 available); any Akt2 mutation (54 available)
Akt3tm1Nhy mutation (0 available); any Akt3 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism




Genotype
MGI:3848166
cx2
Allelic
Composition		 Akt2tm1Rsg/Akt2tm1Rsg
Akt3tm1Nhy/Akt3tm1Nhy
Genetic
Background		 involves: 129/Sv * C57BL/6 * DBA/1LacJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2tm1Rsg mutation (0 available); any Akt2 mutation (54 available)
Akt3tm1Nhy mutation (0 available); any Akt3 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
impaired glucose tolerance ( J:149156 )
• mice exhibit a diabetic phenotype similar to Akt2tm1Rsg homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory