Phenotypes associated with this allele

• Allele Symbol: Timm23^{Gt(W023C08)Wrst}
• Allele Name: gene trap W023C08, Wolfgang Wurst
• Allele ID: MGI:3848025
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Timm23^Gt(W023C08)Wrst/Timm23^Gt(W023C08)Wrst	involves: 129P2/OlaHsd * C57BL/6	MGI:3848027
ht2	Timm23^Gt(W023C08)Wrst/Timm23^+	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J	MGI:3848029
ht3	Timm23^Gt(W023C08)Wrst/Timm23^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3848028

Genotype
MGI:3848027

hm1

• Allelic Composition: Timm23^{Gt(W023C08)Wrst}/Timm23^{Gt(W023C08)Wrst}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:149173 )

• no mice are recovered at E3.5

Genotype
MGI:3848029

ht2

• Allelic Composition: Timm23^{Gt(W023C08)Wrst}/Timm23⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * C57BL/6J

normal phenotype

no abnormal phenotype detected ( J:149173 )

• Background Sensitivity: phenotypes observed on a mixed129P2/OlaHsd and C57BL/6 background become progressively weaker with successive breeding to a mixed 129S2/SvPas and C57BL/6J background and mice appear normal by the fifth generation

Genotype
MGI:3848028

ht3

• Allelic Composition: Timm23^{Gt(W023C08)Wrst}/Timm23⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

premature death ( J:149173 )

• mortality up to 9 months of age is increased compared to in wild-type mice

premature aging ( J:149173 )

• mice exhibit symptoms of premature aging including alopecia and kyphosis

behavior/neurological

impaired coordination ( J:149173 )

• male mice spend less time on a rotarod compared with wild-type mice

decreased grip strength ( J:149173 )

• grip strength is decreased in female mice compared to with wild-type mice

skeleton

kyphosis ( J:149173 )

integument

alopecia ( J:149173 )