Phenotypes associated with this allele

• Allele Symbol: Elovl5^{Gt(DTM098)Byg}
• Allele Name: gene trap DTM098, BayGenomics
• Allele ID: MGI:3847980
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Elovl5^Gt(DTM098)Byg/Elovl5^Gt(DTM098)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:3848006

Genotype
MGI:3848006

hm1

• Allelic Composition: Elovl5^{Gt(DTM098)Byg}/Elovl5^{Gt(DTM098)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

hepatic steatosis ( J:149093 )

• mice develop hepatic steatosis

• liver triglyceride concentrations are 1.6-fold higher in male mice and 2.4-fold higher in female mice

• liver diacylglyceride levels are about 2-fold higher than controls

• liver cholesterol levels are about 2-fold higher in female mice but are normal in male mice

• liver levels of gamma-linolenic are increased 24-fold

• liver levels of mono-saturated fats are increased 2.4 to 4.5 fold

• liver synthesis of fatty acids is more than 2-fold higher than controls

• triglyceride synthesis in the liver is also 2.9-fold higher than controls

abnormal liver physiology ( J:149093 )

• the ability of liver microsomes to elongate gamma-linolenic and stearidonic acids is reduced by about 90%

• liver microsomes fail to elongate palmitoleic, stearic, oleic, linoleic, linolenic, and arachidic acids

• liver microsomes have an enhanced ability to elongate other fatty acids such as palmitic acid, arachidonic eicosapentaenoic, docosatetraenoic , and docosapentaenoic acid

reproductive system

female infertility ( J:149093 )

♀ • majority of females are infertile