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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl2l1Plt16
platelet 16
MGI:3847886
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bcl2l1Plt16/Bcl2l1Plt16 involves: BALB/c * C57BL/6 MGI:3847897
ht2
 		Bcl2l1Plt16/Bcl2l1+ involves: BALB/c * C57BL/6 MGI:3847898
ht3
 		Bcl2l1Plt20/Bcl2l1Plt16 involves: BALB/c * C57BL/6 MGI:3847900


Genotype
MGI:3847897
hm1
Allelic
Composition		 Bcl2l1Plt16/Bcl2l1Plt16
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1Plt16 mutation (0 available); any Bcl2l1 mutation (104 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:149205 )
• very few fetuses survive until birth




Genotype
MGI:3847898
ht2
Allelic
Composition		 Bcl2l1Plt16/Bcl2l1+
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1Plt16 mutation (0 available); any Bcl2l1 mutation (104 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased megakaryocyte cell number ( J:149205 )
• megakaryocyte numbers are marginally elevated compared to controls
thrombocytopenia ( J:149205 )
• platelet counts are significantly lower than controls (596x103/microliter vs 1100x103/microliter)
abnormal platelet physiology ( J:149205 )
• platelet half-life is significantly reduced compared to controls (57 hours to 30 hours)

homeostasis/metabolism
abnormal platelet physiology ( J:149205 )
• platelet half-life is significantly reduced compared to controls (57 hours to 30 hours)




Genotype
MGI:3847900
ht3
Allelic
Composition		 Bcl2l1Plt20/Bcl2l1Plt16
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1Plt16 mutation (0 available); any Bcl2l1 mutation (104 available)
Bcl2l1Plt20 mutation (1 available); any Bcl2l1 mutation (104 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thrombocytopenia ( J:149205 )
• platelet counts are 25% of normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory