Phenotypes associated with this allele

• Allele Symbol: Tfr2^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:3847279
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tfr2^m1Btlr/Tfr2^m1Btlr	C57BL/6J-Tfr2^m1Btlr	MGI:3847280

Genotype
MGI:3847280

hm1

• Allelic Composition: Tfr2^m1Btlr/Tfr2^m1Btlr
• Genetic Background: C57BL/6J-Tfr2^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating ferritin level ( J:148982 )

• homozygous mutant mice have elevated ferritin levels

abnormal iron homeostasis ( J:148982 )

• mutant mice have reduced levels of hepcidin, the primary systemic iron regulator

increased circulating iron level ( J:148982 )

• mice homozygous for this mutation exhibit elevated serum iron levels