All Phenotypes Lepr<brta> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lepr^brta
alberta
MGI:3847119

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lepr^brta/Lepr^brta	C57BL/6JSfdAnu-Lepr^brta/Anu	MGI:3847120

Allelic Composition	Lepr^brta/Lepr^brta
Genetic Background	C57BL/6JSfdAnu-Lepr^brta/Anu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepr^brta mutation (2 available); any Lepr mutation (123 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

obese ( J:104190 )

• mice homozygous for this mutation develop severe obesity that is evident by the time they are 4-8 weeks of age

homeostasis/metabolism

hyperglycemia ( J:104190 )

• homozygous mutant mice develop diabetes by 6 weeks of age

reproductive system

infertility ( J:104190 )

• homozygous mutants do not breed

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
obesity	DOID:9970	OMIM:601665	J:104190
type 2 diabetes mellitus	DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:104190

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24