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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Col14a1tm1Debi
targeted mutation 1, David E Birk
MGI:3846440
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Col14a1tm1Debi/Col14a1tm1Debi involves: 129S4/SvJae * C57BL/6 MGI:3846441
ht2
 		Col14a1tm1Debi/Col14a1+ involves: 129S4/SvJae * C57BL/6 MGI:3846442


Genotype
MGI:3846441
hm1
Allelic
Composition		 Col14a1tm1Debi/Col14a1tm1Debi
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col14a1tm1Debi mutation (0 available); any Col14a1 mutation (80 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Altered fibroblast and fiber organization in P4 tendons from Col14a1tm1Debi/Col14a1tm1Debi mice

muscle
abnormal tendon morphology ( J:148619 )
• while fibril distribution is still unimodal at P4 the distribution width is increased and there is a shift towards larger fibrils
• at P60, tendons have a prominent subpopulation of large diameter fibrils not seen in wild-type controls
abnormal muscle physiology ( J:148619 )
• significant reduction in flexor digitorum longus maximum load and modulus at P7
• however, no difference in tendon biomechanical properties is seen at P60
decreased tendon stiffness ( J:148619 )
• in the flexor digitorum longus at P7

skeleton
abnormal tendon morphology ( J:148619 )
• while fibril distribution is still unimodal at P4 the distribution width is increased and there is a shift towards larger fibrils
• at P60, tendons have a prominent subpopulation of large diameter fibrils not seen in wild-type controls
decreased tendon stiffness ( J:148619 )
• in the flexor digitorum longus at P7

integument
decreased skin tensile strength ( J:148619 )
• maximum stress and modulus are significantly reduced




Genotype
MGI:3846442
ht2
Allelic
Composition		 Col14a1tm1Debi/Col14a1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col14a1tm1Debi mutation (0 available); any Col14a1 mutation (80 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
decreased tendon stiffness ( J:148619 )
• in the flexor digitorum longus at P7 compared to wild-type mice
• however, no difference in tendon biomechanical properties is seen at P60

skeleton
decreased tendon stiffness ( J:148619 )
• in the flexor digitorum longus at P7 compared to wild-type mice
• however, no difference in tendon biomechanical properties is seen at P60




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory