Phenotypes associated with this allele

• Allele Symbol: Nedd4l^tm1.2Blyg
• Allele Name: targeted mutation 1.2, Baoli Yang
• Allele ID: MGI:3846431
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nedd4l^tm1.2Blyg/Nedd4l^tm1.2Blyg	involves: 129X1/SvJ * C57BL/6J	MGI:3846434

Genotype
MGI:3846434

hm1

• Allelic Composition: Nedd4l^tm1.2Blyg/Nedd4l^tm1.2Blyg
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased heart left ventricle weight ( J:148641 )

• in mice on a high salt diet for 8 to 10 months compared to similarly treated littermate controls

decreased cardiac muscle contractility ( J:148641 )

• decreased ejection fraction in mice on a high salt diet for 8 to 10 months compared to similarly treated littermate controls or to mice on a normal diet

decreased heart rate ( J:148641 )

• in mice on a high salt diet for 8 to 10 months compared to similarly treated littermate controls

abnormal systemic arterial blood pressure ( J:148641 )

• absence of normal diurnal variation in blood pressure in mice on a high salt diet

hypertension ( J:148641 )

• in mice on a normal diet

• treatment with amiloride significantly reduces blood pressure in mutants but not in littermate controls

salt-sensitive hypertension ( J:148641 )

• 2 weeks on a high salt diet increases blood pressure in mutants but not in littermate controls

behavior/neurological

increased fluid intake ( J:148641 )

• when placed on a high salt diet the increase in water consumption is greater than that in controls

digestive/alimentary system

decreased intestinal epithelial sodium ion transmembrane transport ( J:148641 )

• being on a high salt diet fails to suppress rectal potential difference

homeostasis/metabolism

increased circulating aldosterone level ( J:148641 )

• in mice on a low salt diet

increased circulating potassium level ( J:148641 )

• slight but significant increase in mice on a normal diet

increased circulating sodium level ( J:148641 )

• when placed on a high salt diet the increase in plasma sodium levels is greater than that in controls

renal/urinary system

polyuria ( J:148641 )

• when placed on a high salt diet the increase in urine output is greater than that in controls

muscle

decreased cardiac muscle contractility ( J:148641 )

• decreased ejection fraction in mice on a high salt diet for 8 to 10 months compared to similarly treated littermate controls or to mice on a normal diet