Phenotypes associated with this allele

• Allele Symbol: Del(2)Pax6^12Neu
• Allele Name: deletion, Chr 2, Neuherberg 12
• Allele ID: MGI:3845767
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(2)Pax6^12Neu/Del(2)Pax6^12Neu	involves: 102 * C3H	MGI:4943213
ht2	Del(2)Pax6^12Neu/+	involves: 102 * C3H	MGI:4943209

Genotype
MGI:4943213

hm1

• Allelic Composition: Del(2)Pax6^12Neu/Del(2)Pax6^12Neu
• Genetic Background: involves: 102 * C3H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:151902 )

• homozygous lethal at an early embryonic stage

Genotype
MGI:4943209

ht2

• Allelic Composition: Del(2)Pax6^12Neu/+
• Genetic Background: involves: 102 * C3H

vision/eye

abnormal eye morphology ( J:151902 )

• at E15.5

irregularly shaped pupil ( J:151902 )

• triangular-shaped

abnormal cornea epithelium morphology ( J:151902 )

• mice exhibit persistent epithelial cells in the cornea unlike in wild-type mice

increased cornea thickness ( J:151902 )

• thickened cornea

fused cornea and lens ( J:151902 )

absent eye anterior chamber ( J:151902 )

lens vacuoles ( J:151902 )

• vacuoles are present in the anterior region of the lens unlike wild-type mice

microphthalmia ( J:151902 )

• at P35, mice exhibit small eye size and decreased eye weight compared with wild-type mice

eye opacity ( J:151902 )

• median eye opacity is 75%

nervous system

abnormal forebrain morphology ( J:151902 )

• mice exhibit reduced diameter of the marginal zone in the dorsal pallial region compared with wild-type mice

abnormal cortical ventricular zone morphology ( J:151902 )

• mice exhibit increased diameter of the ventricular and subventricular zone compared with wild-type mice

telencephalon hypoplasia ( J:151902 )

• mice exhibit hypoplasia in the telencephalic frontal area compared with wild-type mice

abnormal postnatal subventricular zone morphology ( J:151902 )

• mice exhibit increased diameter of the ventricular and subventricular zone compared with wild-type mice

growth/size/body

decreased body weight ( J:151902 )

pigmentation

pigmentation phenotype ( J:151902 )

N • mice exhibit normal belly pigmentation