Phenotypes associated with this allele

• Allele Symbol: Del(2)Pax6^11Neu
• Allele Name: deletion, Chr 2, Neuherberg 11
• Allele ID: MGI:3845668
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(2)Pax6^11Neu/Del(2)Pax6^11Neu	involves: 102 * C3H	MGI:4943214
ht2	Del(2)Pax6^11Neu/+	involves: 102 * C3H	MGI:4943206

Genotype
MGI:4943214

hm1

• Allelic Composition: Del(2)Pax6^11Neu/Del(2)Pax6^11Neu
• Genetic Background: involves: 102 * C3H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:151902 )

• homozygous lethal at an early embryonic stage

Genotype
MGI:4943206

ht2

• Allelic Composition: Del(2)Pax6^11Neu/+
• Genetic Background: involves: 102 * C3H

vision/eye

abnormal eye morphology ( J:151902 )

• at E15.5

abnormal iris pigmentation ( J:151902 )

• reduced

increased cornea thickness ( J:151902 )

• thickened cornea

fused cornea and lens ( J:151902 )

absent eye anterior chamber ( J:151902 )

coloboma ( J:151902 )

• posterior and iris coloboma

iris coloboma ( J:151902 )

abnormal eye distance/ position ( J:151902 )

• eyes are rotated such that the medial-lateral eye axis is 45 degree angle to the dorsal-ventral axis of the head unlike in wild-type mice

microphthalmia ( J:151902 )

• at P35, mice exhibit extreme small eye size and decreased eye weight compared with wild-type mice

nervous system

abnormal forebrain morphology ( J:151902 )

• mice exhibit reduced diameter of the marginal zone in the dorsal pallial region compared with wild-type mice

abnormal cortical ventricular zone morphology ( J:151902 )

• mice exhibit increased diameter of the ventricular and subventricular zone compared with wild-type mice

telencephalon hypoplasia ( J:151902 )

• mice exhibit hypoplasia in the telencephalic frontal area compared with wild-type mice

abnormal postnatal subventricular zone morphology ( J:151902 )

• mice exhibit increased diameter of the ventricular and subventricular zone compared with wild-type mice

growth/size/body

decreased body weight ( J:151902 )

pigmentation

pigmentation phenotype ( J:151902 )

N • mice exhibit normal belly pigmentation

abnormal iris pigmentation ( J:151902 )

• reduced