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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wnt4tm2(EGFP/cre/ERT2)Amc
targeted mutation 2, Andrew P McMahon
MGI:3845544
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Wnt4tm2(EGFP/cre/ERT2)Amc/Wnt4+ involves: 129/Sv * 129S/SvEv * C57BL/6 * C57BL/6J MGI:7543488
cx2
 		Sox7tm1.1Dsco/Sox7+
Wnt4tm2(EGFP/cre/ERT2)Amc/Wnt4+ 		involves: 129/Sv * 129S/SvEv * C57BL/6 * C57BL/6J MGI:7543479


Genotype
MGI:7543488
ht1
Allelic
Composition		 Wnt4tm2(EGFP/cre/ERT2)Amc/Wnt4+
Genetic
Background		 involves: 129/Sv * 129S/SvEv * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt4tm2(EGFP/cre/ERT2)Amc mutation (1 available); any Wnt4 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality during fetal growth through weaning, incomplete penetrance ( J:338879 )
• although present in normal ratios at E15.5/E16.5, heterozygotes are recovered at lower than Mendelian ratios at weaning; however, increase in lethality between E15.5/E16.5 and weaning does not reach statistical significance

cardiovascular system
cardiovascular system phenotype ( J:338879 )
N
• no ventricular septal defects were identified at E15.5
atrioventricular cushion hypoplasia ( J:338879 )
• at E10.5, atrioventricular (AV) endocardial cushions are hypocellular with a significant reduction in mesenchymal cell density relative to wild-type and single Sox7tm1.1Dsco heterozygous controls




Genotype
MGI:7543479
cx2
Allelic
Composition		 Sox7tm1.1Dsco/Sox7+
Wnt4tm2(EGFP/cre/ERT2)Amc/Wnt4+
Genetic
Background		 involves: 129/Sv * 129S/SvEv * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox7tm1.1Dsco mutation (0 available); any Sox7 mutation (21 available)
Wnt4tm2(EGFP/cre/ERT2)Amc mutation (1 available); any Wnt4 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality during fetal growth through weaning, incomplete penetrance ( J:338879 )
• although present in normal ratios at E15.5/E16.5, double heterozygotes are recovered at lower than Mendelian ratios at weaning; however, increase in lethality between E15.5/E16.5 and weaning does not reach statistical significance

cardiovascular system
atrioventricular cushion hypoplasia ( J:338879 )
• at E10.5, atrioventricular (AV) endocardial cushions are hypocellular with a significant reduction in mesenchymal cell density relative to wild-type and single heterozygous controls
ventricular septal defect ( J:338879 )
• at E15.5, three of 8 (38%) of double heterozygotes develop VSDs, not observed in wild-type or single heterozygous controls
perimembraneous ventricular septal defect ( J:338879 )
• at E15.5, two of 8 double heterozygotes develop perimembranous VSDs
muscular ventricular septal defect ( J:338879 )
• at E15.5, one of 8 double heterozygotes shows a muscular VSD




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory