Phenotypes associated with this allele

• Allele Symbol: Mpz^ttrr
• Allele Name: totterer
• Allele ID: MGI:3844951
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mpz^ttrr/Mpz^ttrr	B6.Cg-Mpz^ttrr/GrsrJ	MGI:3849294

Genotype
MGI:3849294

hm1

• Allelic Composition: Mpz^ttrr/Mpz^ttrr
• Genetic Background: B6.Cg-Mpz^ttrr/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:149880 )

nervous system

demyelination ( J:149880 )

• homozyogtes assessed from 18 weeks of age through 33 weeks of age show varying degrees and stages of peripheral demyelination

behavior/neurological

tremors ( J:149880 )

• mild tremors are first seen at approximately 2 weeks of age

abnormal gait ( J:149880 )

• progressive muscle weakness results in a shaking limb grasping, hunched, sprawled, tottering gait by 6 to 8 weeks of age

hindlimb paralysis ( J:149880 )

• late-onset paralysis of the rear legs

reproductive system

infertility ( J:149880 )

• females and males often fail to breed and those that do breed only breed once or twice

female infertility ( J:149880 )

♀

male infertility ( J:149880 )

♂