Phenotypes associated with this allele

• Allele Symbol: Extl3^tm1Okam
• Allele Name: targeted mutation 1, Hiroshi Okamoto
• Allele ID: MGI:3844733
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Extl3^tm1.1Okam/Extl3^tm1Okam Tg(Ins2-cre)#Okam/0	involves: 129P2/OlaHsd * ICR	MGI:4366326

Genotype
MGI:4366326

cn1

• Allelic Composition: Extl3^tm1.1Okam/Extl3^tm1Okam; Tg(Ins2-cre)#Okam/0
• Genetic Background: involves: 129P2/OlaHsd * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased pancreatic beta cell mass ( J:148348 )

• decreased beta-cell area relative to the whole pancreatic area (75%)

• no difference in the islet size

decreased pancreatic beta cell number ( J:148348 )

• decreased beta-cell number/total islet cell number ratio (80%) after 2 weeks of age

disorganized pancreatic islets ( J:148348 )

• beta-cells exist also in the most peripheral region of the islets after 2 weeks of age

• glucagonspositive alpha-cells are scattered in the central region after 2 weeks of age

• islets develop normally at birth

decreased insulin secretion ( J:148348 )

• decreased insulin response to 11.2 mM glucose (47%)

• decreased insulin response to 20 mM KCl (75%)

homeostasis/metabolism

decreased insulin secretion ( J:148348 )

• decreased insulin response to 11.2 mM glucose (47%)

• decreased insulin response to 20 mM KCl (75%)

decreased circulating insulin level ( J:148348 )

• decreased plasma insulin levels after glucose loading

impaired glucose tolerance ( J:148348 )

• significantly higher blood glucose levels in the glucose tolerance test

• no peripheral insulin resistance in the insulin tolerance test

cellular

decreased cell proliferation ( J:148348 )

• significantly decreased pancreatic islet beta-cell proliferation activity