Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm2(Nfatc2*)Rao}
• Allele Name: targeted mutation 2, Anjana Rao
• Allele ID: MGI:3844635
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm2(Nfatc2*)Rao/Gt(ROSA)26Sor^+ Tg(CMV-cre)1Cgn/0	involves: BALB/cJ	MGI:3844640
cn2	Gt(ROSA)26Sor^tm2(Nfatc2*)Rao/Gt(ROSA)26Sor^+ Tg(Cd4-cre)1Cwi/0	involves: C57BL/6 * DBA/2	MGI:3844643

Genotype
MGI:3844640

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm2(Nfatc2*)Rao}/Gt(ROSA)26Sor⁺; Tg(CMV-cre)1Cgn/0
• Genetic Background: involves: BALB/cJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:148341 )

• fewer than expected mice with this genotype are found

hematopoietic system

abnormal hematopoietic system morphology/development ( J:148341 )

• the fraction of B and T cells expressing the recombined allele decreases during differentiation and maturation

Genotype
MGI:3844643

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm2(Nfatc2*)Rao}/Gt(ROSA)26Sor⁺; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: C57BL/6 * DBA/2

immune system

abnormal T cell activation ( J:148341 )

• hyperresponsive to stimulation

abnormal interferon level ( J:148341 )

• increased production of IFNG following low level stimulation

homeostasis/metabolism

abnormal interferon level ( J:148341 )

• increased production of IFNG following low level stimulation

hematopoietic system

abnormal T cell activation ( J:148341 )

• hyperresponsive to stimulation