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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm2(Nfatc2*)Rao
targeted mutation 2, Anjana Rao
MGI:3844635
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm2(Nfatc2*)Rao/Gt(ROSA)26Sor+
Tg(CMV-cre)1Cgn/0 		involves: BALB/cJ MGI:3844640
cn2
 		Gt(ROSA)26Sortm2(Nfatc2*)Rao/Gt(ROSA)26Sor+
Tg(Cd4-cre)1Cwi/0 		involves: C57BL/6 * DBA/2 MGI:3844643


Genotype
MGI:3844640
cn1
Allelic
Composition		 Gt(ROSA)26Sortm2(Nfatc2*)Rao/Gt(ROSA)26Sor+
Tg(CMV-cre)1Cgn/0
Genetic
Background		 involves: BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(Nfatc2*)Rao mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Tg(CMV-cre)1Cgn mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:148341 )
• fewer than expected mice with this genotype are found

hematopoietic system
abnormal hematopoietic system morphology/development ( J:148341 )
• the fraction of B and T cells expressing the recombined allele decreases during differentiation and maturation




Genotype
MGI:3844643
cn2
Allelic
Composition		 Gt(ROSA)26Sortm2(Nfatc2*)Rao/Gt(ROSA)26Sor+
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(Nfatc2*)Rao mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Tg(Cd4-cre)1Cwi mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell activation ( J:148341 )
• hyperresponsive to stimulation
abnormal interferon level ( J:148341 )
• increased production of IFNG following low level stimulation

homeostasis/metabolism
abnormal interferon level ( J:148341 )
• increased production of IFNG following low level stimulation

hematopoietic system
abnormal T cell activation ( J:148341 )
• hyperresponsive to stimulation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory