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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tfb1mtm1.2Lrsn
targeted mutation 1.2, Nils-Goran Larsson
MGI:3844231
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tfb1mtm1.2Lrsn/Tfb1mtm1.2Lrsn involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL MGI:3844253


Genotype
MGI:3844253
hm1
Allelic
Composition		 Tfb1mtm1.2Lrsn/Tfb1mtm1.2Lrsn
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfb1mtm1.2Lrsn mutation (0 available); any Tfb1m mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:148166 )
• although present at E8.5, no live mice are born

nervous system
open neural tube ( J:148166 )
• at E8.5, the neural cleft is open
absent optic disk ( J:148166 )
• absent at E8.5

cardiovascular system
absent heart ( J:148166 )
• at E8.5, no heart structure is present

embryo
open neural tube ( J:148166 )
• at E8.5, the neural cleft is open

cellular
abnormal respiratory electron transport chain ( J:148166 )
• at E8.5, mitochondrial respiratory chain function is decreased compared to in wild-type embryos

vision/eye
absent optic disk ( J:148166 )
• absent at E8.5

growth/size/body
decreased embryo size ( J:148166 )
• at E8.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory