Phenotypes associated with this allele

• Allele Symbol: Slc12a1^tm2Haca
• Allele Name: targeted mutation 2, Hayo Castrop
• Allele ID: MGI:3843784
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc12a1^tm2Haca/Slc12a1^tm2Haca	involves: 129S/SvEv * FVB/N	MGI:3843795

Genotype
MGI:3843795

hm1

• Allelic Composition: Slc12a1^tm2Haca/Slc12a1^tm2Haca
• Genetic Background: involves: 129S/SvEv * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal circulating magnesium level ( J:148062 )

increased circulating renin level ( J:148062 )

• following administration of saline intravenously, mice exhibit less of a drop in renin plasma levels compared to in similarly treated wild-type mice

abnormal renal water reabsorption ( J:148062 )

• at high perfusion flows, water absorption is decreased compared to in wild-type mice

decreased urine osmolality ( J:148062 )

• ambient urine osmolarity is reduced compared to in wild-type mice

• however, urine osmolarity responds normally to water deprivation

renal/urinary system

decreased urine osmolality ( J:148062 )

• ambient urine osmolarity is reduced compared to in wild-type mice

• however, urine osmolarity responds normally to water deprivation

abnormal renal reabsorption ( J:148062 )

• at high perfusion flows, chloride ion concentration in the distal tubule is elevated and chloride ion absorption is low compared to in wild-type mice

abnormal renal water reabsorption ( J:148062 )

• at high perfusion flows, water absorption is decreased compared to in wild-type mice

decreased tubuloglomerular feedback response ( J:148062 )

• at a saturating perfusion rate of 30 nl/min, the maximum tubuloglomerular feedback is reduced compared to in wild-type mice

increased tubuloglomerular feedback response ( J:148062 )

• at low perfusion rates, tubuloglomerular feedback responsiveness is increased compared to in wild-type mice