Phenotypes associated with this allele

• Allele Symbol: Bdnf^tm1Bail
• Allele Name: targeted mutation 1, Bai Lu
• Allele ID: MGI:3842639
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bdnf^tm1Bail/Bdnf^tm1Bail	B6.129-Bdnf^tm1Bail	MGI:3842650

Genotype
MGI:3842650

hm1

• Allelic Composition: Bdnf^tm1Bail/Bdnf^tm1Bail
• Genetic Background: B6.129-Bdnf^tm1Bail

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain interneuron morphology ( J:147571 )

• calretinin positive interneurons of the medial prefrontal cortex are increased

• total number of GABAergic interneurons of the prefrontal cortex are unaffected

• 7% reduction of parvalbumin positive interneurons in the medial prefrontal cortex

• calbindin positive interneurons of the medial prefrontal cortex are slightly decreased

abnormal nervous system physiology ( J:147571 )

abnormal synaptic plasticity ( J:147571 )

• robust spike time dependent potentiation lasting longer than 30 minutes resulting from pairing presynaptic with subsequent post-synaptic action potential induced layer V pyramidal neuron stimulation

decreased inhibitory postsynaptic current amplitude ( J:147571 )

• mean amplitude of spontaneous IPSCs (sIPSCs) in layer V pyramidal neurons is markedly reduced in the presence of AMPA and NMDA receptor antagonist in all neurons from medial prefrontal complex (mPFC) slices

• glutamate receptor function as determined by rise time and decay time is unaffected

decreased inhibitory postsynaptic current frequency ( J:147571 )

• mean sIPSC frequency is reduced to about half of the wild-type value