nervous system
• calretinin positive interneurons of the medial prefrontal cortex are increased
• total number of GABAergic interneurons of the prefrontal cortex are unaffected
• 7% reduction of parvalbumin positive interneurons in the medial prefrontal cortex
• calbindin positive interneurons of the medial prefrontal cortex are slightly decreased
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• robust spike time dependent potentiation lasting longer than 30 minutes resulting from pairing presynaptic with subsequent post-synaptic action potential induced layer V pyramidal neuron stimulation
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• spontaneous IPSC in layer V pyramidal neurons is markedly reduced in the presence of AMPA and NMDA receptor antagonist
• frequency is reduced by half
• glutamate receptor function as determined by rise time and decay time is unaffected
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