Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meg3tm1Kono mutation
(0 available);
any
Meg3 mutation
(4 available)
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mortality/aging
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N |
• mice survive into adulthood
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growth/size/body
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• mice weight less than wild-type mice but are intermediate to heterozygous mice when the allele is inherited maternally or paternally
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Allelic
Composition |
Meg3tm1Kono/Meg3+
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Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6N * DBA/2 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meg3tm1Kono mutation
(0 available);
any
Meg3 mutation
(4 available)
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mortality/aging
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• when this allele is inherited paternally, only one quarter of expected mice survive to reproduce
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• mice die within 4 weeks regardless of whether the allele is inherited maternally or paternally
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• when this allele is inherited paternally, half of mice born die within a few days after birth
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• when this allele is inherited paternally, the number of mice born is lower than expected
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growth/size/body
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• more so when this allele is inherited paternally than when it is inherited maternally
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• regardless of whether the allele is inherited maternally or paternally, mice fail to maintain the same growth rate as wild-type mice
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liver/biliary system
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• when this allele is inherited maternally, mice develop hepatocellular necrosis unlike wild-type mice
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respiratory system
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• when this allele is inherited maternally, mice develop severely hypoplastic pulmonary alveoli diagnosed by incomplete development of alveolar sacs along with the formation of a thin respiratory epithelium unlike wild-type mice
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cellular
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• when this allele is inherited maternally, mice develop hepatocellular necrosis unlike wild-type mice
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Analysis Tools