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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Cga-cre)1Awo
transgene insertion 1, Andrew Wolfe
MGI:3842442
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Esr1tm1.2Awo/Esr1tm1.2Awo
Tg(Cga-cre)1Awo/0 		involves: C57BL/6 * SJL MGI:4360656


Genotype
MGI:4360656
cn1
Allelic
Composition		 Esr1tm1.2Awo/Esr1tm1.2Awo
Tg(Cga-cre)1Awo/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esr1tm1.2Awo mutation (0 available); any Esr1 mutation (67 available)
Tg(Cga-cre)1Awo mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:152925 )
N
• male mice exhibit normal fertility
absent corpus luteum ( J:152925 )
• in infertile mice
decreased corpora lutea number ( J:152925 )
• in mice with decreased fertility
abnormal ovarian follicle morphology ( J:152925 )
• atretic follicles and primary and secondary follicles fail to reach the periphery of the ovary unlike in wild-type mice
female infertility ( J:152925 )
• despite the presence of vaginal plus, 5 of 9 mice are infertile unlike wild-type mice
reduced female fertility ( J:152925 )
• 4 of 9 mice

endocrine/exocrine glands
absent corpus luteum ( J:152925 )
• in infertile mice
decreased corpora lutea number ( J:152925 )
• in mice with decreased fertility
abnormal ovarian follicle morphology ( J:152925 )
• atretic follicles and primary and secondary follicles fail to reach the periphery of the ovary unlike in wild-type mice

homeostasis/metabolism
abnormal luteinizing hormone level ( J:152925 )
• luteinizing hormone basal levels are higher than in wild-type mice, values fail to surge with the estrous cycle, and peak levels are 18-fold lower than in wild-type mice
decreased circulating luteinizing hormone level ( J:152925 )
• peak levels are 18-fold lower than in wild-type mice
increased circulating luteinizing hormone level ( J:152925 )
• basal luteinizing hormone serum levels are 4-fold higher than in wild-type mice

nervous system




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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory