Phenotypes associated with this allele

• Allele Symbol: Cyp11b2^tm2Hsk
• Allele Name: targeted mutation 2, Hyung-Suk Kim
• Allele ID: MGI:3842189
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cyp11b2^tm2Hsk/Cyp11b2^tm2Hsk	involves: 129S6/SvEvTac	MGI:3842293

Genotype
MGI:3842293

hm1

• Allelic Composition: Cyp11b2^tm2Hsk/Cyp11b2^tm2Hsk
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

hypokalemia ( J:147672 )

• when fed a high salt diet

decreased urine osmolality ( J:147672 )

• when fed a high salt diet

increased urine osmolality ( J:147672 )

• when fed a low salt diet

abnormal enzyme/coenzyme activity ( J:147672 )

• when fed a low salt diet, mice exhibit less deactivation of the renin-angiotensin-aldosterone system compared to in wild-type mice

abnormal response/metabolism to endogenous compounds ( J:147672 )

• mice fed a medium high salt diet and treated with angiotensin II exhibit a greater increase in blood pressure, increase in myocyte cross-sectional area, cardiac fibrosis, and oxidative stress measured by urine 8-isoprotane levels compared to similarly treated wild-type mice

renal/urinary system

decreased urine osmolality ( J:147672 )

• when fed a high salt diet

increased urine osmolality ( J:147672 )

• when fed a low salt diet

oliguria ( J:147672 )

• when fed a low salt diet

polyuria ( J:147672 )

• when fed a high salt diet

cardiovascular system

increased myocardial fiber size ( J:147672 )

• mice fed a medium high salt diet and treated with angiotensin II exhibit a greater increase in myocyte cross-sectional area compared to similarly treated wild-type mice

cardiac fibrosis ( J:147672 )

• mice fed a medium high salt diet and treated with angiotensin II exhibit a greater increase in cardiac fibrosis, especially perivascular, compared to similarly treated wild-type mice

increased systemic arterial blood pressure ( J:147672 )

• when fed a high salt diet, mice exhibit increased blood pressure compared to in similarly treated wild-type mice

• mice fed a medium high salt diet and treated with angiotensin II exhibit a greater increase in blood pressure compared to similarly treated wild-type mice

behavior/neurological

decreased fluid intake ( J:147672 )

• reduced water consumption when fed a low salt diet

cellular

oxidative stress ( J:147672 )

• mice fed a medium high salt diet and treated with angiotensin II exhibit a greater increase in oxidative stress measured by urine 8-isoprotane levels compared to similarly treated wild-type mice

muscle

increased myocardial fiber size ( J:147672 )

• mice fed a medium high salt diet and treated with angiotensin II exhibit a greater increase in myocyte cross-sectional area compared to similarly treated wild-type mice