Analysis Tools
reproductive system
uterus cyst
(
J:147610
)
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• the uteri are enlarged with multiple cysts unlike in wild-type mice
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• female mice are infertile despite normally cycling in young females and the ability of older mice to ovulate when treated with pregnant mare serum and human chorionic gonadotrophin
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homeostasis/metabolism
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• following handling, mice fail to exhibit an increase in plasma corticosterone levels unlike wild-type mice
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• in males, but not female, mice
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hypokalemia
(
J:147610
)
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• in male mice
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• in males, but not female, mice
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• urine contains decreased aldosterone levels compared to in wild-type mice
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• mice exhibit a decrease in corticosterone (9.5-fold and 18-fold in male and female mice, respectively) urine content compared to in wild-type mice
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• urine contains increased progesterone levels compared to in wild-type mice
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• mice exhibit an increase in deoxycorticosterone (27- and 44-fold in males and females, respectively) urine content compared to in wild-type mice
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endocrine/exocrine glands
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• wider than normal due to cell hypertrophy
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• mice exhibit increased adrenal gland size compared to in wild-type mice with female mice exhibiting less hypertrophy than male mice
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• mice exhibit increased adrenal gland size compared to in wild-type mice with female mice exhibiting less hypertrophy than male mice
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• pituitary glands are hypertrophied with an increased in the numbers of corticotropes compared to in wild-type mice
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• in males, but not female, mice
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nervous system
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• pituitary glands are hypertrophied with an increased in the numbers of corticotropes compared to in wild-type mice
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cardiovascular system
renal/urinary system
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• in males, but not female, mice
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• urine contains decreased aldosterone levels compared to in wild-type mice
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• mice exhibit a decrease in corticosterone (9.5-fold and 18-fold in male and female mice, respectively) urine content compared to in wild-type mice
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• urine contains increased progesterone levels compared to in wild-type mice
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• mice exhibit an increase in deoxycorticosterone (27- and 44-fold in males and females, respectively) urine content compared to in wild-type mice
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adipose tissue
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• mice exhibit a decrease in mesenteric, gonadal, subcutaneous, and brown adipose compared to in wild-type mice
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hematopoietic system
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• in males, but not female, mice
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liver/biliary system
immune system
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• in males, but not female, mice
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growth/size/body
uterus cyst
(
J:147610
)
|
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• in males, but not female, mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| congenital adrenal hyperplasia | DOID:0050811 |
OMIM:201710 OMIM:201810 OMIM:201910 OMIM:202010 OMIM:202110 |
J:147610 | |
