Analysis Tools
mortality/aging
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• expected numbers are found at birth but all die before P24
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vision/eye
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• cell loss in the retinal inner nuclear layer is due to loss of amacrine cells
• significant decrease in the number of GABAergic cells
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• increase in the number of cholinergic cells
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• decrease in the cross sectional area
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• increase in the number of ISL1+ cells at the inner edge of the inner neuroblastic layer at P0 - P5
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• a more than 2-fold increase in the number of POU4F2- ISL1+ cells (probably representing displaced cholinergic amacrine cells) is seen
• gradual increase in the number of apoptotic cells compared to controls from E16.5 to P0
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• decrease in cell number is first detectable at E16.5
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• first detectable at E16.5
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• about 36% fewer cells at E16.5
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• first detectable at E16.5
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• at P3, the frequency of nicotinic acetylcholine receptor mediated retinal waves measured at the interwave interval is about 50% lower than in controls
• however, at P13 the frequency of glutamate receptor mediated retinal waves measured at the interwave interval is not significantly different from controls
• the average peak frequency of light-evoked responses of ON?OFF directional selective retinal ganglion cells is significantly decreased compared to controls
• however, the average peak frequency of light-evoked responses of ON retinal ganglion cells is not significantly different from controls
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behavior/neurological
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• gradual development of impaired coordination with age
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growth/size/body
nervous system
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• cell loss in the retinal inner nuclear layer is due to loss of amacrine cells
• significant decrease in the number of GABAergic cells
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• decrease in cell number is first detectable at E16.5
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• increase in the number of cholinergic cells
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• decrease in the cross sectional area
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