Phenotypes associated with this allele

• Allele Symbol: Ifnar2^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:3841008
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ifnar2^m1Btlr/Ifnar2^m1Btlr	C57BL/6J-Ifnar2^m1Btlr	MGI:3841009

Genotype
MGI:3841009

hm1

• Allelic Composition: Ifnar2^m1Btlr/Ifnar2^m1Btlr
• Genetic Background: C57BL/6J-Ifnar2^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage physiology ( J:147329 )

• peritoneal macrophages from homozygous mutant mice are permissive to infection with mouse cytomegalovirus (MCMV), influenza virus, Rift Valley Fever virus and an adenoviral vector

• homozygous mutant macrophages are defective in the production of type I intereron in response to double-stranded DNA

decreased interferon-alpha secretion ( J:147329 )

• homozygous mutant peritoneal macrophages are defective in the production of type I intereron in response to double-stranded DNA

decreased interferon-beta secretion ( J:147329 )

• homozygous mutant peritoneal macrophages are defective in the production of type I intereron in response to double-stranded DNA

increased susceptibility to Adenoviridae infection ( J:147329 )

• peritoneal macrophages isolated from mice homozygous for this mutation fail to clear infection by an adenovirus vector

increased susceptibility to Herpesvirales infection ( J:147329 )

• peritoneal macrophages isolated from mice homozygous for this mutation fail to clear infection by mouse cytomegalovirus (MCMV)

increased susceptibility to Riboviria infection ( J:147329 )

• peritoneal macrophages isolated from mice homozygous for this mutation fail to clear infection by Rift Valley fever virus (RVFV)

increased susceptibility to Orthomyxoviridae infection ( J:147329 )

• peritoneal macrophages isolated from mice homozygous for this mutation fail to clear infection by influenza virus

hematopoietic system

abnormal macrophage physiology ( J:147329 )

• peritoneal macrophages from homozygous mutant mice are permissive to infection with mouse cytomegalovirus (MCMV), influenza virus, Rift Valley Fever virus and an adenoviral vector

• homozygous mutant macrophages are defective in the production of type I intereron in response to double-stranded DNA