Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shhtm1Chg mutation
(1 available);
any
Shh mutation
(45 available)
Tg(Prrx1-Sox9,-lacZ)1Haak mutation
(1 available)
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limbs/digits/tail
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• at E13.5 limb bud morphology is the same as that in null mice that do not express the transgene
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embryo
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• at E13.5 limb bud morphology is the same as that in null mice that do not express the transgene
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa13Hd mutation
(1 available);
any
Hoxa13 mutation
(29 available)
Tg(Prrx1-Sox9,-lacZ)1Haak mutation
(1 available)
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limbs/digits/tail
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• on the hindlimb digit 1 is present but small
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• the proximal phalanx of hindlimb digit 1 is incomplete
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• pre and post axial polydactyly
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skeleton
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• the proximal phalanx of hindlimb digit 1 is incomplete
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prrx1-Sox9,-lacZ)1Haak mutation
(1 available)
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limbs/digits/tail
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• deformed limbs at birth
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• at E13.5, increased cell density is seen in the anterior and posterior limb bud mesenchyme corresponding to areas of transgene expression and cell proliferation in the posterior mesechyme is increased
• at E14.5 these excess cells aggregate and for an extra postaxial nubbin
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• short and broad digits 1 and 5 on the fore and hind limbs
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• short and broad digits 1 and 5 on the fore and hind limbs
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• a post axial nubbin is present on the hindlimbs
• skeletal preparations show pre and post axial polydactyly
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• after 2 weeks of age mice walk with the backside of their forelimbs facing down towards the ground
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• very short limbs at birth
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skeleton
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• the chondrogenic mesenchymal condensation of the ulna is larger resulting in formation of a short but large cartilage primordia of the ulna
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• delayed endochondral bone formation is seen in the humerus, ulna, radius, and digits 1 and 5 at birth
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embryo
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• at E13.5, increased cell density is seen in the anterior and posterior limb bud mesenchyme corresponding to areas of transgene expression and cell proliferation in the posterior mesechyme is increased
• at E14.5 these excess cells aggregate and for an extra postaxial nubbin
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prrx1-Sox9,-lacZ)1Haak mutation
(1 available)
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limbs/digits/tail
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• pre and post axial polydactyly
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prrx1-Sox9,-lacZ)1Haak mutation
(1 available)
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cardiovascular system
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N |
• no major abnormalities in limb vascular patterning are detected
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Analysis Tools