Phenotypes associated with this allele

• Allele Symbol: In(2Hoxd11;Itga6)1Ddu
• Allele Name: inversion, Chr 2, Denis Duboule 1
• Allele ID: MGI:3840855
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	In(2Hoxd11;Itga6)1Ddu/In(2Hoxd11;Itga6)1Ddu	involves: 129S1/Sv * 129X1/SvJ	MGI:3840890
ht2	In(2Hoxd11;Itga6)1Ddu/+	involves: 129S1/Sv * 129X1/SvJ	MGI:3840889

Genotype
MGI:3840890

hm1

• Allelic Composition: In(2Hoxd11;Itga6)1Ddu/In(2Hoxd11;Itga6)1Ddu
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Axial skeleton abnormalities in heterozygous and homozygous In(2Hoxd11;Itga6)1Ddu mice

skeleton

sternebra fusion ( J:146752 )

• sternebrae 4 and 5 are fused

abnormal sternocostal joint morphology ( J:146752 )

• mice exhibit a misalignment of the first rib to the sternum

abnormal cervical vertebrae morphology ( J:146752 )

• C7 exhibits protrusion of ectopic bony material from the transverse process unlike in wild-type mice

increased lumbar vertebrae number ( J:146752 )

• 7 of 9 mice have a seventh lumbar vertebrae

sacral vertebral transformation ( J:146752 )

• 7 of 9 mice exhibit S1 to L7 transformation

Genotype
MGI:3840889

ht2

• Allelic Composition: In(2Hoxd11;Itga6)1Ddu/+
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Axial skeleton abnormalities in heterozygous and homozygous In(2Hoxd11;Itga6)1Ddu mice

skeleton

abnormal cervical vertebrae morphology ( J:146752 )

• C7 exhibits protrusion of ectopic bony material from the transverse process unlike in wild-type mice