Analysis Tools
mortality/aging
|
• severely affected (runt) mice (5 of 23) died by 2 months of age
• less severely affected (non-runt) mice die between 2 and 7 months of age
|
|
• 5 of 28 live born mice died within 2 to 3 days of birth
|
|
• about half die before birth
|
growth/size/body
|
• increase in the heart to body weight ratio in non-runt mice
|
|
• of mice that survive to weaning, some (5 of 23, runts) weigh less than 40% of normal weaning weight while the remainder (non-runts) are smaller than controls but not as severely affected
|
|
• at weaning some severely affected mice (5 of 23) are very small and fail to thrive
|
skeleton
|
• a few non-runt mice show transformation of T7 to T6 (3 of 13) and of T4 to T3 (2 of 13)
|
|
• a few non-runt mice (2 of 13) show transformation of L6 to S1
|
|
• non-runt mice show failure of fusion of the lateral processes on S1 - S3
|
|
• in all non-runt mice the lateral processes of S3 resemble those of S4 indicating transformation of S3 to S4
• some non-runt mice show transformation of S2 to S3
|
|
• in non-runt mice splitting is seen at multiple locations in the cervical and thoracic regions
|
behavior/neurological
cardiovascular system
|
• cardiomyocyte disarray
|
|
• increase in the heart to body weight ratio in non-runt mice
|
|
• seen in older, moribund non-runt mice
|
cellular
|
• seen in older, moribund non-runt mice
|
