Analysis Tools
hematopoietic system
| N |
• KSL hematopoietic stem cells are normal
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Allele Symbol Allele Name Allele ID |
Cdkn1ctm1.1(Cdkn1b*)Kei targeted mutation 1.1, Keiichi I Nakayama MGI:3840687 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• KSL hematopoietic stem cells are normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Representative testes, seminal vesicles, and uteri from wild-type, Cdkn1ctm1Kat/Cdkn1c+, and Cdkn1ctm1.1(Cdkn1b*)Kei/Cdkn1c+ mice at 7 weeks of age
| N |
• unlike null mice, all knock in mice survive
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• all mice carry a maternally inherited mutant allele
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| N |
• unlike null mice, knock in mice grow at a rate similar to controls
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• thinning of the abdominal wall or omphalocele are seen
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• thinning of the abdominal wall or omphalocele are seen
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• dysplasia
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• enlargement is less pronounced compared to null mice
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• present in 2 of 9 mice
• incidence is decreased compared to null mice
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• present in 3 of 15 mice
• incidence is decreased compared to null mice
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• dysplasia
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| N |
• cleft palate and shortening of the intestines seen in null mice are largely corrected in knock in mice
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| N |
• unlike null mice, knock in mice do not develop cataracts and do not display increased cell proliferation in the lens
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| N |
• rib and vertebral deformities, delayed bone ossification, decreased length of the long bones, and aberrant cell proliferation seen in null mice are largely corrected in knock in mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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