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Allele Symbol Allele Name Allele ID |
Bmpertm1Cpat targeted mutation 1, Cam Patterson MGI:3840517 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Bmpertm1Cpat/Bmpertm1Cpat mice die at birth and have widespread tissue-specific defects
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• mice die at birth
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• mice exhibit widespread tissue-specific defects during embryonic development
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Delayed branching morphogenesis and inadequately expanded alveoli in Bmpertm1Cpat/Bmper+ lungs
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• overgrowth of mesenchymal cells appears to prevent complete alveoli expansion with smaller and fewer terminal sacs that are separated by thickened interstitial mesenchyme unlike in wild-type mice
• at E18.5, lungs have fewer apoptotic cells than in wild-type lungs
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• branching morphogenesis in the lung is delayed compared to in wild-type mice
• however, lung differentiation and cell proliferation are normal
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• smaller and fewer terminal sacs separated by thickened interstitial mesenchyme
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• at E18.5, the ratio of type II epithelial cells to total distal cells is increased compared to in wild-type mice
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• mice exhibit widespread tissue-specific defects during embryonic development
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• in a model of oxygen-induced retinopathy (5 days of hyperoxia followed by hypoxia), mutants show an increased rate of retinal revascularization and faster recovery of the retinal vascular bed
• hypoxic retinas show a more dense and complex network of newly formed vessels, with increased numbers of branching points and angiogenic sprouts at the leading edge of the newly formed vasculature
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• in a model of oxygen-induced retinopathy (5 days of hyperoxia followed by hypoxia), mutants show an increased rate of retinal revascularization and faster recovery of the retinal vascular bed
• hypoxic retinas show a more dense and complex network of newly formed vessels, with increased numbers of branching points and angiogenic sprouts at the leading edge of the newly formed vasculature
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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