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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Axin1tm4Cos
targeted mutation 4, Frank Costantini
MGI:3840238
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Axin1tm4Cos/Axin1tm4Cos involves: 129S6/SvEvTac * FVB/N MGI:3840266
ht2
 		Axin1tm3Cos/Axin1tm4Cos involves: 129S6/SvEvTac * FVB/N MGI:3840267
cx3
 		Axin1tm4Cos/Axin1tm4Cos
Ctnnb1tm2.1Kem/Ctnnb1+ 		involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:3840269


Genotype
MGI:3840266
hm1
Allelic
Composition		 Axin1tm4Cos/Axin1tm4Cos
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Axin1tm4Cos mutation (0 available); any Axin1 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:147293 )
• mice are resorbed by E11.5

embryo
embryonic growth retardation ( J:147293 )
• developmental delay at E9.5
incomplete rostral neuropore closure ( J:147293 )
• at E9.5, 14 of 32 mice exhibit opened and shortened head folds unlike wild-type

cardiovascular system
cardia bifida ( J:147293 )
• in 14 of 32 mice at E9.5
enlarged pericardium ( J:147293 )
• in 13 of 32 mice at E9.5

nervous system
incomplete rostral neuropore closure ( J:147293 )
• at E9.5, 14 of 32 mice exhibit opened and shortened head folds unlike wild-type

craniofacial
shortened head ( J:147293 )
• truncated head at E9.5

growth/size/body
shortened head ( J:147293 )
• truncated head at E9.5
embryonic growth retardation ( J:147293 )
• developmental delay at E9.5
decreased embryo size ( J:147293 )




Genotype
MGI:3840267
ht2
Allelic
Composition		 Axin1tm3Cos/Axin1tm4Cos
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Axin1tm3Cos mutation (0 available); any Axin1 mutation (44 available)
Axin1tm4Cos mutation (0 available); any Axin1 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:147293 )
• mice die prior to E12.5

embryo
abnormal embryo development ( J:147293 )
• some embryos are located outside of the yolk sac
embryonic growth retardation ( J:147293 )
• developmental delay at E9.5

nervous system

growth/size/body
embryonic growth retardation ( J:147293 )
• developmental delay at E9.5




Genotype
MGI:3840269
cx3
Allelic
Composition		 Axin1tm4Cos/Axin1tm4Cos
Ctnnb1tm2.1Kem/Ctnnb1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Axin1tm4Cos mutation (0 available); any Axin1 mutation (44 available)
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:147293 )
N
• unlike Axin1tm4Cos homozygotes, mice survive until E18.5 when they are sacrificed

craniofacial
abnormal nose morphology ( J:147293 )
• mice lack nasal structures unlike wild-type mice

respiratory system
abnormal nose morphology ( J:147293 )
• mice lack nasal structures unlike wild-type mice

nervous system
abnormal brain morphology ( J:147293 )
• mice have multiple brain malformations unlike wild-type mice

digestive/alimentary system

growth/size/body
abnormal head morphology ( J:147293 )
abnormal facial morphology ( J:147293 )
cleft palate ( J:147293 )
abnormal nose morphology ( J:147293 )
• mice lack nasal structures unlike wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory