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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Axin1tm3Cos
targeted mutation 3, Frank Costantini
MGI:3840236
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Axin1tm3Cos/Axin1tm3Cos involves: 129S6/SvEvTac * FVB/N MGI:3840265
ht2
 		Axin1tm3Cos/Axin1tm4Cos involves: 129S6/SvEvTac * FVB/N MGI:3840267


Genotype
MGI:3840265
hm1
Allelic
Composition		 Axin1tm3Cos/Axin1tm3Cos
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Axin1tm3Cos mutation (0 available); any Axin1 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
abnormal embryo development ( J:147293 )
• at E9.5 all mice are severely abnormal and indistinguishable from Axin1Fu-Tg1 homozygotes
abnormal embryo turning ( J:147293 )
• mice fail to turn
embryonic growth retardation ( J:147293 )
• developmental delay at E9.5
incomplete rostral neuropore closure ( J:147293 )
• the head folds are open and shortened compared to in wild-type mice

cardiovascular system

nervous system
incomplete rostral neuropore closure ( J:147293 )
• the head folds are open and shortened compared to in wild-type mice

craniofacial
shortened head ( J:147293 )
• truncated head at E9.5

growth/size/body
shortened head ( J:147293 )
• truncated head at E9.5
embryonic growth retardation ( J:147293 )
• developmental delay at E9.5
decreased embryo size ( J:147293 )
• at E9.5
decreased body length ( J:147293 )
• mice exhibit underdeveloped trunks compared to wild-type mice




Genotype
MGI:3840267
ht2
Allelic
Composition		 Axin1tm3Cos/Axin1tm4Cos
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Axin1tm3Cos mutation (0 available); any Axin1 mutation (42 available)
Axin1tm4Cos mutation (0 available); any Axin1 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:147293 )
• mice die prior to E12.5

embryo
abnormal embryo development ( J:147293 )
• some embryos are located outside of the yolk sac
embryonic growth retardation ( J:147293 )
• developmental delay at E9.5

nervous system

growth/size/body
embryonic growth retardation ( J:147293 )
• developmental delay at E9.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory