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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mre11atm2.1Dof
targeted mutation 2.1, David O Ferguson
MGI:3839939
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mre11atm1Dof/Mre11atm2.1Dof involves: 129S6/SvEvTac MGI:3839952
cn2
 		Mre11atm2.1Dof/Mre11atm2.2Dof Not Specified MGI:3839953


Genotype
MGI:3839952
cn1
Allelic
Composition		 Mre11atm1Dof/Mre11atm2.1Dof
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mre11atm1Dof mutation (0 available); any Mre11a mutation (48 available)
Mre11atm2.1Dof mutation (0 available); any Mre11a mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:147247 )
N
• cre-treated mouse embryonic fibroblasts exhibit normal G2/M checkpoint activation following exposure to ionizing radiation
increased cellular sensitivity to ionizing radiation ( J:147247 )
• cre-treated mouse embryonic fibroblasts exhibit increased cellular sensitivity to ionizing radiation compared to similarly treated heterozygous cells that is not as severe as in Lig4tm1Fwa cells
• cre-treated mouse embryonic fibroblasts exhibit defective DNA repair following treatment with ionizing radiation compared to in similarly treated heterozygous mice
decreased cell proliferation ( J:147247 )
• cre-exposed mouse embryonic fibroblasts exhibit decreased growth rates by the second passage and no increase in numbers beyond passage three unlike similarly treated heterozygous cells
abnormal DNA repair ( J:147247 )
• cre-treated mouse embryonic fibroblasts exhibit defective DNA repair following treatment with ionizing radiation compared to in wild-type mice
chromosomal instability ( J:147247 )
• cre-exposed mouse embryonic fibroblasts (MEFs) exhibit chromosomal instability including chromosome or chromatid fragments, chromosome breaks or gaps in a single chromatid, occasional radial structures, and dicentrics unlike in similarly treated heterozygous cells
• following exposure to gamma radiation, cre-exposed MEFs fail to exhibit a downward trend in frequency of chromosomal anomalies unlike similarly treated heterozygous cells
induced chromosome breakage ( J:147247 )
• cre-treated mouse embryonic fibroblasts exhibit hypersensitivity to aphidicolin compared to similarly treated heterozygous cells

homeostasis/metabolism
abnormal DNA repair ( J:147247 )
• cre-treated mouse embryonic fibroblasts exhibit defective DNA repair following treatment with ionizing radiation compared to in wild-type mice




Genotype
MGI:3839953
cn2
Allelic
Composition		 Mre11atm2.1Dof/Mre11atm2.2Dof
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mre11atm2.1Dof mutation (0 available); any Mre11a mutation (48 available)
Mre11atm2.2Dof mutation (0 available); any Mre11a mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell cycle checkpoint function ( J:147247 )
• cre-treated mouse embryonic fibroblasts exposed to ionizing radiation exhibit a defect in the G2/M checkpoint compared to similarly treated heterozygous cells
increased cellular sensitivity to ionizing radiation ( J:147247 )
• cre-treated mouse embryonic fibroblasts exhibit increased cellular sensitivity to ionizing radiation compared to similarly treated heterozygous cells that is not as severe as in Lig4tm1Fwa cells
• cre-treated mouse embryonic fibroblasts exhibit defective DNA repair following treatment with ionizing radiation compared to in similarly treated heterozygous cells
decreased cell proliferation ( J:147247 )
• cre-exposed mouse embryonic fibroblasts exhibit decreased growth rates by the second passage and no increase in numbers beyond passage three unlike similarly treated heterozygous cells
abnormal DNA repair ( J:147247 )
• cre-treated mouse embryonic fibroblasts exhibit defective DNA repair following treatment with ionizing radiation compared to in similarly treated heterozygous cells
chromosomal instability ( J:147247 )
• cre-exposed mouse embryonic fibroblasts (MEFs) exhibit chromosomal instability including chromosome or chromatid fragments, chromosome breaks or gaps in a single chromatid, occasional radial structures, and dicentrics unlike in similarly treated heterozygous cells
• MEFs exhibit more genomic instability compared to in Lig4tm1Fwa MEFs
• following exposure to gamma radiation, cre-exposed MEFs fail to exhibit a downward trend in frequency of chromosomal anomalies unlike similarly treated heterozygous cells
induced chromosome breakage ( J:147247 )
• cre-treated mouse embryonic fibroblasts exhibit hypersensitivity to aphidicolin compared to similarly treated heterozygous cells

homeostasis/metabolism
abnormal DNA repair ( J:147247 )
• cre-treated mouse embryonic fibroblasts exhibit defective DNA repair following treatment with ionizing radiation compared to in similarly treated heterozygous cells




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory