Phenotypes associated with this allele

• Allele Symbol: Klf13^tm1Kren
• Allele Name: targeted mutation 1, Alan M Krensky
• Allele ID: MGI:3839530
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klf13^tm1Kren/Klf13^tm1Kren	B6.129-Klf13^tm1Kren	MGI:3839534

Genotype
MGI:3839534

hm1

• Allelic Composition: Klf13^tm1Kren/Klf13^tm1Kren
• Genetic Background: B6.129-Klf13^tm1Kren

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased thymocyte apoptosis ( J:145839 )

• reduced thymocyte apoptosis

• resistant to apoptosis inducing agents

decreased splenocyte apoptosis ( J:145839 )

• splenocytes resistant to apoptosis inducing agents

abnormal immune system cell morphology ( J:145839 )

abnormal T cell number ( J:145839 )

decreased thymocyte number ( J:145839 )

• TCRbeta (+) thymocytes are decreased in number

increased thymocyte number ( J:145839 )

• particularly pronounced in young mice

• becomes less pronounced with age

• prolonged thymocyte survival

increased double-positive T cell number ( J:145839 )

• numbers in the thymus are consistently elevated

abnormal immune system organ morphology ( J:145839 )

thymus hyperplasia ( J:145839 )

• thymus structure is normal aside from the increase in size

abnormal spleen morphology ( J:145839 )

spleen hyperplasia ( J:145839 )

• spleen structure is normal aside from the increase in size

increased splenocyte number ( J:145839 )

• remain elevated at all ages examined

hematopoietic system

decreased thymocyte apoptosis ( J:145839 )

• reduced thymocyte apoptosis

• resistant to apoptosis inducing agents

decreased splenocyte apoptosis ( J:145839 )

• splenocytes resistant to apoptosis inducing agents

thymus hyperplasia ( J:145839 )

• thymus structure is normal aside from the increase in size

abnormal T cell number ( J:145839 )

decreased thymocyte number ( J:145839 )

• TCRbeta (+) thymocytes are decreased in number

increased thymocyte number ( J:145839 )

• particularly pronounced in young mice

• becomes less pronounced with age

• prolonged thymocyte survival

increased double-positive T cell number ( J:145839 )

• numbers in the thymus are consistently elevated

abnormal spleen morphology ( J:145839 )

spleen hyperplasia ( J:145839 )

• spleen structure is normal aside from the increase in size

increased splenocyte number ( J:145839 )

• remain elevated at all ages examined

cellular

decreased thymocyte apoptosis ( J:145839 )

• reduced thymocyte apoptosis

• resistant to apoptosis inducing agents

decreased splenocyte apoptosis ( J:145839 )

• splenocytes resistant to apoptosis inducing agents

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:145839 )

• reduced thymocyte apoptosis

• resistant to apoptosis inducing agents

thymus hyperplasia ( J:145839 )

• thymus structure is normal aside from the increase in size

decreased thymocyte number ( J:145839 )

• TCRbeta (+) thymocytes are decreased in number

increased thymocyte number ( J:145839 )

• particularly pronounced in young mice

• becomes less pronounced with age

• prolonged thymocyte survival

growth/size/body

spleen hyperplasia ( J:145839 )

• spleen structure is normal aside from the increase in size