Analysis Tools
mortality/aging
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• some mice die between E14.5 and E18.5
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• mice found alive at E18.5 do not survive more than a few hours after birth by Caesarean section
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vision/eye
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• the ventral portion is thickened at E14.5
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• ventral rotation is seen at E14.5
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• at E14.5 all mice have a persistent and hyperplasic primary vitreous body
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• closer eyelid folds in mice at E14.5
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• small optic disc coloboma is seen in 90% of mice at E14.5 but not in any mice at E18.5 suggesting a delay in optic disc formation
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• shortened ventral retina at E14.5
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• agenesis of the sclera is seen in all mice at E18.5
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cardiovascular system
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• seen in 1 of 10 mice at E14.5 but not in any mice at E18.5
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• hypoplasia of the compact layer of the ventricular myocardium is seen in 20% (2 of 10) of mice at E14.5 and in 1 of 3 mice at E18.5
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• agenesis of the conotruncal septum is seen in 1 of 10 mice at E14.5
• however, no mice show absence of the membranous portion of the ventricular septum at E18.5
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digestive/alimentary system
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• agenesis of the sublingual gland ducts at E18.5
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embryo
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• seen in 1 of 10 mice at E14.5 but not in any mice at E18.5
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• at E14.5 - E18.5, the boundary between the spongiotrophoblast and labyrinth is ill defined
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• at E14.5 - E18.5, labyrinthine trabeculae appear abnormally thick
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growth/size/body
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• at E18.5 live mice weigh about 1/3 less than controls
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endocrine/exocrine glands
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• agenesis of the sublingual gland ducts at E18.5
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• at E18.5
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nervous system
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• small optic disc coloboma is seen in 90% of mice at E14.5 but not in any mice at E18.5 suggesting a delay in optic disc formation
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craniofacial
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• seen in 1 of 10 mice at E14.5 but not in any mice at E18.5
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muscle
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• hypoplasia of the compact layer of the ventricular myocardium is seen in 20% (2 of 10) of mice at E14.5 and in 1 of 3 mice at E18.5
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