Phenotypes associated with this allele

• Allele Symbol: Eri1^tm1.2Anse
• Allele Name: targeted mutation 1.2, K Mark Ansel
• Allele ID: MGI:3838637
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eri1^tm1.2Anse/Eri1^tm1.2Anse	involves: BALB/cJ * C57BL/6 * ICR * SJL	MGI:3838649
hm2	Eri1^tm1.2Anse/Eri1^tm1.2Anse	involves: BALB/cJ * C57BL/6 * SJL	MGI:3838648

Genotype
MGI:3838649

hm1

• Allelic Composition: Eri1^tm1.2Anse/Eri1^tm1.2Anse
• Genetic Background: involves: BALB/cJ * C57BL/6 * ICR * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:146701 )

• Background Sensitivity: just over 10% of mice survive to weaning unlike on a more inbred background where less than 10% survive to weaning

Genotype
MGI:3838648

hm2

• Allelic Composition: Eri1^tm1.2Anse/Eri1^tm1.2Anse
• Genetic Background: involves: BALB/cJ * C57BL/6 * SJL

mortality/aging

postnatal lethality, incomplete penetrance ( J:146701 )

• although born in Mendelian ratios, less than 10% of mice survive to weaning with most mice dieing within the first 2 days after birth

• Background Sensitivity: just under 10% of mice survive to weaning unlike on an outbred background where more than 10% survive to weaning

growth/size/body

decreased body size ( J:146701 )

• throughout adulthood

decreased fetal size ( J:146701 )

• at E15.5

cellular

decreased cell proliferation ( J:146701 )

• mouse embryonic fibroblasts grow slower than wild-type cells after 6 to 9 passages