Phenotypes associated with this allele

• Allele Symbol: Pdgfra^tm12.1Sor
• Allele Name: targeted mutation 12.1, Philippe Soriano
• Allele ID: MGI:3838514
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Pdgfra^tm12.1Sor/Pdgfra^+	involves: 129 * C57BL/6	MGI:3838617

Genotype
MGI:3838617

ht1

• Allelic Composition: Pdgfra^tm12.1Sor/Pdgfra⁺
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:146617 )

• while mice are present in Mendelian ratios at E18.5, no mice are present at P14

renal/urinary system

abnormal kidney pelvis morphology ( J:146617 )

• as early as E16.5, the renal pelvis is enlarged unlike in wild-type mice

abnormal ureter morphology ( J:146617 )

• mice exhibit stromal cell hyperplasia in the ureter unlike in wild-type mice

abnormal ureter development ( J:146617 )

• at E13.5, more mesenchymal cells are found in the ureters compared to in wild-type mice likely due to increased migration

• however, cell proliferation in ureters is normal at E13.5

abnormal ureter smooth muscle morphology ( J:146617 )

• ureters exhibit poorly condensed smooth muscle cells unlike in wild-type mice

ureter obstruction ( J:146617 )

• due to stromal cell hyperplasia

respiratory system

pulmonary hyperplasia ( J:146617 )

• at E18.5

abnormal lung development ( J:146617 )

• at E18.5, mice exhibit a failure of terminal sac morphogenesis with lung development only reaching the canalicular stage

increased mesenchymal cell proliferation involved in lung development ( J:146617 )

• at E18.5, mice exhibit 1.6-fold increase in mesenchymal cell density

digestive/alimentary system

esophagus hyperplasia ( J:146617 )

• stromal cell hyperplasia

abnormal stomach morphology ( J:146617 )

• mice exhibit hyperplasia of stromal cells in the stomach compared to in wild-type mice

cellular

increased fibroblast chemotaxis ( J:146617 )

• in culture, fibroblasts exhibit increased migration towards PDGF-AA compared to wild-type cells

increased cell proliferation ( J:146617 )

• at E13.5, esophageal cells exhibit increased proliferation compared to in wild-type mice

• however, cell proliferation in ureters is normal at E13.5

increased fibroblast proliferation ( J:146617 )

• in culture, primary fibroblasts exhibit increased growth potential compared to wild-type cells

increased mesenchymal cell proliferation involved in lung development ( J:146617 )

• at E18.5, mice exhibit 1.6-fold increase in mesenchymal cell density

growth/size/body

esophagus hyperplasia ( J:146617 )

• stromal cell hyperplasia

increased embryo size ( J:146617 )

• from E12.5 to E16.5

increased fetal size ( J:146617 )

• from E12.5 to E16.5

pulmonary hyperplasia ( J:146617 )

• at E18.5

skeleton

abnormal sternum morphology ( J:146617 )

• at E18.5, mice have a wide, unsegmented sternum unlike in wild-type mice

• sternal bands are unfused

wide sternum ( J:146617 )

• at E18.5

abnormal rib morphology ( J:146617 )

• ribs exhibit incomplete contact

embryo

increased embryo size ( J:146617 )

• from E12.5 to E16.5

abnormal mesenchyme morphology ( J:146617 )

• embryos exhibit uncondensed mesenchyme

immune system

abnormal immune system organ morphology ( J:146617 )

• lymphatic structures are enlarged during late fetal development

homeostasis/metabolism

edema ( J:146617 )

• in the torso in embryos