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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fcgrttm1Esw
targeted mutation 1, E Sally Ward
MGI:3838491
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fcgrttm1Esw/Fcgrttm1Esw
Tg(Tek-cre)1Ywa/0 		B6.Cg-Tg(Tek-cre)1Ywa Fcgrttm1Esw MGI:3838507


Genotype
MGI:3838507
cn1
Allelic
Composition		 Fcgrttm1Esw/Fcgrttm1Esw
Tg(Tek-cre)1Ywa/0
Genetic
Background		 B6.Cg-Tg(Tek-cre)1Ywa Fcgrttm1Esw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgrttm1Esw mutation (1 available); any Fcgrt mutation (60 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal humoral immune response ( J:146640 )
• half-life of IgG1 antibodies (measured by clearance of injected human IgG1) is much shorter than controls with a mean half-life of 8.2 hours compared to 169.8 hours for controls
decreased IgG1 level ( J:146640 )
• serum levels of IgG1 are 4-fold less than controls

homeostasis/metabolism
decreased circulating serum albumin level ( J:146640 )
• albumin levels are about half that of controls

hematopoietic system
decreased IgG1 level ( J:146640 )
• serum levels of IgG1 are 4-fold less than controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory