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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zbtb7bhpls
helpless
MGI:3838356
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zbtb7bhpls/Zbtb7bhpls involves: C57BL/6JAnu MGI:5298030


Genotype
MGI:5298030
hm1
Allelic
Composition		 Zbtb7bhpls/Zbtb7bhpls
Genetic
Background		 involves: C57BL/6JAnu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb7bhpls mutation (2 available); any Zbtb7b mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:104190 )
• very few in peripheral blood and thymus

immune system
decreased CD4-positive, alpha-beta T cell number ( J:104190 )
• very few in peripheral blood and thymus
abnormal humoral immune response ( J:104190 )
• mice fail to mount a normal primary T cell-dependent antibody response




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory