Analysis Tools
cardiovascular system
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• very mild
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• in 2 of 13 mice without signs of distress
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• maximum rate of pressure development and relaxation rates are reduced compared to in wild-type mice
• the Starling responses in a Frank-Starling relationship graph are compromised with a modest decrease in slope compared to in wild-type mice
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• the first derivative of the increase in left ventricle systolic pressure with respect to time, a measure of contractility, is decreased 44% compared to in wild-type mice
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• the first derivative of the decrease in left ventricular systolic pressure with respect to time, a measure of relaxation, is decreased 42% compared to in wild-type hearts
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homeostasis/metabolism
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• in 2 of 13 mice without signs of distress
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muscle
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• very mild
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• the first derivative of the increase in left ventricle systolic pressure with respect to time, a measure of contractility, is decreased 44% compared to in wild-type mice
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• the first derivative of the decrease in left ventricular systolic pressure with respect to time, a measure of relaxation, is decreased 42% compared to in wild-type hearts
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growth/size/body
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• in 2 of 13 mice without signs of distress
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