Phenotypes associated with this allele

• Allele Symbol: Pard3^tm1.1Shoh
• Allele Name: targeted mutation 1.1, Shigeo Ohno
• Allele ID: MGI:3838017
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pard3^tm1.1Shoh/Pard3^tm1.1Shoh	involves: 129S4/SvJae * C57BL/6 * C57BL/6J	MGI:3838101

Genotype
MGI:3838101

hm1

• Allelic Composition: Pard3^tm1.1Shoh/Pard3^tm1.1Shoh
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:146415 )

• 25% of mice are dead at E10.5, and no mice are recovered after E12.5

cardiovascular system

abnormal heart development ( J:146415 )

• unlike in wild-type mice, the typical epicardial progenitor cell cysts are not detected at E9.5 to E10.5 and the myocardium is no covered with a single layer of flat cells at E10.5 to E11.5

• however, epicardial progenitor cell migration and proliferation are normal

heart atrium hypoplasia ( J:146415 )

• in embryos with slight growth retardation at E10.5

increased heart atrium size ( J:146415 )

• in embryos with severe growth retardation at E10.5

ventricular hypoplasia ( J:146415 )

• in embryos with slight growth retardation at E10.5

growth/size/body

embryonic growth retardation ( J:146415 )

• 40% of mice exhibit severe growth retardation at E9.5

• 60% to 75% of mice exhibit mild to slight growth retardation at E9.5

nervous system

abnormal telencephalon development ( J:146415 )

• telencephalic vesicles are prominent unlike in wild-type mice

limbs/digits/tail

short tail ( J:146415 )

• due to caudal defects

homeostasis/metabolism

edema ( J:146415 )

• at E10.5, embryos with severe growth retardation exhibit peripheral edema

embryo

embryonic growth retardation ( J:146415 )

• 40% of mice exhibit severe growth retardation at E9.5

• 60% to 75% of mice exhibit mild to slight growth retardation at E9.5