Phenotypes associated with this allele

• Allele Symbol: Gper1^tm1.1Lmlf
• Allele Name: targeted mutation 1.1, L M Leeb-Lundberg
• Allele ID: MGI:3837567
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gper1^tm1.1Lmlf/Gper1^tm1.1Lmlf	B6.129-Gper1^tm1.1Lmlf	MGI:3837658

Genotype
MGI:3837658

hm1

• Allelic Composition: Gper1^tm1.1Lmlf/Gper1^tm1.1Lmlf
• Genetic Background: B6.129-Gper1^tm1.1Lmlf

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased glucagon secretion ( J:146345 )

• however, male mice exhibit normal glucagons secretion in response to glucose stimulation

• female mice exhibit slightly reduced glucagons release in response to low (18%) and high-glucose (12%) compared to in wild-type mice

• PGE2-treated islet cells fail to exhibit decreased glucagons in response to glucose stimulation unlike wild-type cells

decreased insulin secretion ( J:146345 )

• in response to low and high glucose levels, female mice exhibit a 35% and 57%, respectively, decrease in insulin release compared to similarly treated wild-type mice

• however, the fold stimulation by glucose, tolbutamide and high potassium ion is normal

• ovariectomized female mice failed to exhibit an increase in pancreatic insulin content unlike similarly treated wild-type mice

• treatment of ovariectomized female mice with PGE2 fail to increase pancreatic insulin content unlike in similarly treated wild-type mice

• PGE2-treated islet cells fails to increases insulin release in response to glucose stimulation unlike in similarly treated wild-type cells

increased circulating glucose level ( J:146345 )

• 13% in female mice at 6 months of age

decreased circulating glucagon level ( J:146345 )

• female mice exhibit depressed glucagons levels 10 minutes after glucose challenge compared to wild-type mice

decreased circulating insulin-like growth factor I level ( J:146345 )

• in female mice, but not in male mice, at 6 months of age

impaired glucose tolerance ( J:146345 )

• female mice exhibit diminished first-phase insulin response to glucose challenge compared to similarly treated wild-type mice

• however, male mice exhibit normal glucose tolerance

abnormal response/metabolism to endogenous compounds ( J:146345 )

• normal insulin and glucagon response to PGE2 is abolished

endocrine/exocrine glands

decreased glucagon secretion ( J:146345 )

• female mice exhibit slightly reduced glucagons release in response to low (18%) and high-glucose (12%) compared to in wild-type mice

• however, male mice exhibit normal glucagons secretion in response to glucose stimulation

• PGE2-treated islet cells fail to exhibit decreased glucagons in response to glucose stimulation unlike wild-type cells

decreased insulin secretion ( J:146345 )

• in response to low and high glucose levels, female mice exhibit a 35% and 57%, respectively, decrease in insulin release compared to similarly treated wild-type mice

• however, the fold stimulation by glucose, tolbutamide and high potassium ion is normal

• ovariectomized female mice failed to exhibit an increase in pancreatic insulin content unlike similarly treated wild-type mice

• treatment of ovariectomized female mice with PGE2 fail to increase pancreatic insulin content unlike in similarly treated wild-type mice

• PGE2-treated islet cells fails to increases insulin release in response to glucose stimulation unlike in similarly treated wild-type cells

growth/size/body

decreased body weight ( J:146345 )

• in female mice only

decreased body length ( J:146345 )

• in female mice only

cardiovascular system

artery stenosis ( J:146345 )

• at 9 months, the lumen circumference of resistance arteries is reduced 23% and media to lumen ratio is increased 45% compared to in wild-type mice

• however, mice exhibit normal thoracic arteries dimensions and media thickness

increased mean systemic arterial blood pressure ( J:146345 )

• at 9 months, female mice exhibit a 23% elevation in mean arterial blood pressure compared to in wild-type mice

limbs/digits/tail

short femur ( J:146345 )

• in female mice only

skeleton

short femur ( J:146345 )

• in female mice only