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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lrp5tm2Kry
targeted mutation 2, Gerard Karsenty
MGI:3837394
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lrp5tm2Kry/Lrp5tm2Kry
Tg(Vil1-cre)20Syr/0 		involves: C57BL/6 * DBA/2 MGI:3837403
cn2
 		Lrp5tm2Kry/Lrp5+
Tg(Vil1-cre)20Syr/0 		involves: C57BL/6 * DBA/2 MGI:3837404
cn3
 		Lrp5tm2Kry/Lrp5tm2Kry
Tg(Col1a1-cre)1Kry/0 		involves: FVB MGI:3837402


Genotype
MGI:3837403
cn1
Allelic
Composition		 Lrp5tm2Kry/Lrp5tm2Kry
Tg(Vil1-cre)20Syr/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5tm2Kry mutation (0 available); any Lrp5 mutation (83 available)
Tg(Vil1-cre)20Syr mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased osteoblast proliferation ( J:146078 )
• decreased osteoblast proliferation

homeostasis/metabolism
abnormal serotonin level ( J:146078 )
• circulating serotonin levels are 5- to 8-fold higher compared to controls

skeleton
decreased osteoblast proliferation ( J:146078 )
• decreased osteoblast proliferation
decreased bone ossification ( J:146078 )
• decreased bone formation

vision/eye
vision/eye phenotype ( J:146078 )
N
• unlike in null mice, persistence of hyaloid vessels is not seen




Genotype
MGI:3837404
cn2
Allelic
Composition		 Lrp5tm2Kry/Lrp5+
Tg(Vil1-cre)20Syr/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5tm2Kry mutation (0 available); any Lrp5 mutation (83 available)
Tg(Vil1-cre)20Syr mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
decreased bone ossification ( J:146078 )
• decreased bone formation




Genotype
MGI:3837402
cn3
Allelic
Composition		 Lrp5tm2Kry/Lrp5tm2Kry
Tg(Col1a1-cre)1Kry/0
Genetic
Background		 involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5tm2Kry mutation (0 available); any Lrp5 mutation (83 available)
Tg(Col1a1-cre)1Kry mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:146078 )
N
• unlike in null mice, circulating serotonin levels are similar to controls

skeleton
skeleton phenotype ( J:146078 )
N
• unlike in null mice, bone mass and osteoblast proliferation are normal

vision/eye
vision/eye phenotype ( J:146078 )
N
• unlike in null mice, persistence of hyaloid vessels is not seen




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory