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Allele Symbol Allele Name Allele ID |
Mthfd1Gt(XB175)Byg gene trap XB175, BayGenomics MGI:3837220 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice fed a folate and choline deficient diet (FCD) exhibit a 40% greater reduction in the levels of S-adenosylmethionine in the liver compared to similarly treated wild-type mice
• however, S-adenosylmethionine levels in the colon are normal and normally reduced in mice fed an FCD diet
• when fed a standard diet, mice exhibit decreased concentrations of cystathionine compared to in wild-type mice
• whether fed a standard or FCD diet, mice exhibit higher levels of alpha-aminobutyric acid compared to in similarly treated wild-type mice without exhibiting an increase in levels when fed the FCD unlike wild-type mice
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• C1THF synthase is decreased 50% in the kidney, liver, colon, and brain compared to in wild-type mice
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• when fed a folate and choline deficient diet, mice less of an increase in the uracil content of DNA in the colon compared to similarly treated wild-type mice
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• at weaning and the following two weeks, mice exhibit increased body weight compared to wild-type mice regardless of diet
• however, three to five weeks after weaning mice weigh as much as wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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