All Phenotypes Lmna<tm4Lgf> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lmna^tm4Lgf
targeted mutation 4, Loren G Fong
MGI:3837135

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Lmna^tm4Lgf/Lmna⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3837138

Allelic Composition	Lmna^tm4Lgf/Lmna⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmna^tm4Lgf mutation (0 available); any Lmna mutation (82 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Rib fractures in Lmna^tm4Lgf/Lmna⁺ and Lmna^tm1Lgf/Lmna⁺ mice

mortality/aging

premature death ( J:146099 )

• mice die between 35 and 45 weeks

cellular

abnormal cell nucleus morphology ( J:146099 )

• mouse embryonic fibroblasts exhibit misshapen nuclei unlike wild-type cells

growth/size/body

decreased body weight ( J:146099 )

skeleton

rib fractures ( J:146099 )

• mice exhibit more rib fractures than in wild-type mice but less than in Lmna^tm1Lgf heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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