Analysis Tools
immune system
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• CD4+ T cell numbers are reduced by about half in the spleen and lymph nodes
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• CD8+ T cell numbers in the spleen and lymph node are only 66% of that found in wild-type
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• spleen size is significantly reduced mostly due to a reduction in the number of T cells
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• when transferred into a immunocompetent syngeneic host, mutant T cells fail to survive where as wild-type T cells do
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• homeostatic proliferation of T cells is defective as determined by competitive reconstitution assays with wild-type lymph node cells in sublethally irradiated hosts
• homeostatic proliferation is also defective in culture when mutant T cell proliferation is driven by the presence of syngeneic dendritc cells
• antigen driven proliferation is normal in these mice
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hematopoietic system
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• CD4+ T cell numbers are reduced by about half in the spleen and lymph nodes
|
|
• CD8+ T cell numbers in the spleen and lymph node are only 66% of that found in wild-type
|
|
• spleen size is significantly reduced mostly due to a reduction in the number of T cells
|
|
• when transferred into a immunocompetent syngeneic host, mutant T cells fail to survive where as wild-type T cells do
|
|
• homeostatic proliferation of T cells is defective as determined by competitive reconstitution assays with wild-type lymph node cells in sublethally irradiated hosts
• homeostatic proliferation is also defective in culture when mutant T cell proliferation is driven by the presence of syngeneic dendritc cells
• antigen driven proliferation is normal in these mice
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cellular
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• homeostatic proliferation of T cells is defective as determined by competitive reconstitution assays with wild-type lymph node cells in sublethally irradiated hosts
• homeostatic proliferation is also defective in culture when mutant T cell proliferation is driven by the presence of syngeneic dendritc cells
• antigen driven proliferation is normal in these mice
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